Abstract Background Germline TP53 mutations are associated with Li-Fraumeni syndrome, a Centre Tub Seal severe and rare hereditary cancer syndrome.Despite the rarity of germline TP53 mutations, the clinical implication for mutation carriers and their families is significant.The risk management of TP53 germline mutation carriers is more stringent th
Messenger RNA (mRNA)-based vaccines have shown promise against infectious diseases and several types of cancer in the last two decades.Their promise can be attributed to their safety profiles, high potency, and ability to be rapidly and HOOK affordably manufactured.Now, many RNA-based vaccines are being evaluated in clinical trials as prophylactic
A goal of introductory physics for life sciences (IPLS) curricula is to prepare students to Hunter Bridle effectively use physical models and quantitative reasoning in biological and medical settings.To assess whether this goal is being met, we conducted a longitudinal study of the impact of IPLS on student work in later biology and chemistry cours